Nazarenko S A, Burmakina Iu E
Biull Eksp Biol Med. 1984 Sep;98(9):334-6.
The frequency of spontaneous instability of lymphocyte chromosomes of the first 2 mitoses, the rate of sister chromatid exchanges (SCEs), and the proliferative kinetics of lymphocytes were studied in a 6-year-old girl with Fanconi's anemia (FA) and in 4 healthy donors. The frequencies of aberrant cells and the total number of chromosome breaks in the FA patient decreased with cell transition from the first to the second mitosis. The FA lymphocytes had a slower proliferative kinetics and the level of SCEs was higher as compared with control. The probability of chromatid deletions at the sites of SCEs localization and in the dark and light stained chromatids was unequal. 33.8% of chromatid breaks were associated with SCEs. The data point to the relationship between SCEs and spontaneous chromosome instability in AF cells.
对一名患有范可尼贫血（FA）的6岁女孩和4名健康供体的淋巴细胞染色体前2次有丝分裂的自发不稳定性频率、姐妹染色单体交换（SCE）率以及淋巴细胞的增殖动力学进行了研究。随着细胞从第一次有丝分裂过渡到第二次有丝分裂，FA患者中异常细胞的频率和染色体断裂总数减少。与对照组相比，FA淋巴细胞的增殖动力学较慢，SCE水平较高。SCE定位位点以及深色和浅色染色单体中染色单体缺失的概率不相等。33.8%的染色单体断裂与SCE相关。这些数据表明SCE与AF细胞中自发染色体不稳定性之间存在关联。
