Margiotta G, Barbata G, Carbone P, Granata G, Caronia F
Minerva Med. 1981 Sep 22;72(35):2361-5.
In direct preparations of bone marrow cells from an 18 years old patient with Fanconi's anaemia (FA) a low frequency of structural chromosome aberrations was observed (4% excluding gaps), while in cultured bone marrow cells (48 hours) and in cultured peripheral lymphocytes such aberrations were found to be about 3 times as many. The increase of chromosome abnormalities "in vitro" is discussed and the most recent observations on possible factors determining susceptibility to chromosome breakage in cases with FA are taken into account.
在对一名18岁范可尼贫血（FA）患者的骨髓细胞进行直接制片时，观察到结构染色体畸变的频率较低（不包括裂隙为4%），而在培养的骨髓细胞（48小时）和培养的外周血淋巴细胞中，此类畸变的数量约为前者的3倍。文中讨论了“体外”染色体异常的增加情况，并考虑了关于FA患者中决定染色体断裂易感性的可能因素的最新观察结果。
