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Localization chromatid breaks in Fanconi's anemia, using three consecutive stains.

作者信息

Dutrillaux B, Couturier J, Viegas-Péquignot E, Schaison G

出版信息

Hum Genet. 1977 Jun 10;37(1):65-71. doi: 10.1007/BF00293773.

DOI:10.1007/BF00293773
PMID:69603
Abstract

The location of 339 break points was analyzed in three patients with Fanconi's anemia, using three consecutive stains: ordinary Giemsa, Q-banding, and R-banding. Almost all the breaks seem to take place in the Q bands, using R-banding, and in the R bands, using Q-banding. A very important artifact, varying according to the method used, is thus demonstrated. In fact, the breaks take place in the interbands, between R and Q bands. The breaks were also localized in relation to sister chromatid exchanges (SCEs), seen after BUDR treatment. There is a clear excess of breaks at place of SCE (29%). This may indicate a possible correlation between breaks and SCEs.

摘要

相似文献

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Localization chromatid breaks in Fanconi's anemia, using three consecutive stains.
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本文引用的文献

1
Familial constitutional panmyelocytopathy, Fanconi's anemia (F.A.). II. A discussion of the cytogenetic findings in Fanconi's anemia.
Semin Hematol. 1967 Jul;4(3):241-9.
2
[Cytogenetic and cytologic findings in enzymopenic panmyelopathies and pancytopenias. Familial myelopathy of Fanconi, glutathione-reductase deficiency anemia and megaloblastic B12 deficiency anemia].
Humangenetik. 1966;2(3):287-316. doi: 10.1007/BF00395947.
3
Fanconi's anemia. Inherited susceptibility to chromosome breakage in various tissues.范科尼贫血。多种组织中对染色体断裂的遗传性易感性。
Ann Intern Med. 1966 Sep;65(3):496-503. doi: 10.7326/0003-4819-65-3-496.
4
仙人掌鼠（刚毛棉鼠）中一个BrdU敏感位点的分析：染色体断裂与姐妹染色单体交换。
Chromosoma. 1980;77(3):379-89. doi: 10.1007/BF00286062.
4
Nonrandom distribution of exchange points in patients with reciprocal translocations.相互易位患者交换点的非随机分布。
Hum Genet. 1980;56(1):89-93. doi: 10.1007/BF00281575.
5
Spectrum of anomalies in Fanconi anaemia.范可尼贫血中的异常谱
J Med Genet. 1982 Dec;19(6):412-6. doi: 10.1136/jmg.19.6.412.
6
Sister chromatid exchanges and heterochromatin.姐妹染色单体交换与异染色质
Hum Genet. 1981;57(2):119-30. doi: 10.1007/BF00282006.
7
Distribution of break points in human structural rearrangements.人类结构重排中断点的分布。
Am J Hum Genet. 1983 Mar;35(2):288-300.
8
Isoacentric and isocentric chromosomes originating after deletions of human chromosomes.人类染色体缺失后产生的等臂染色体和等中心染色体。
Hum Genet. 1987 Jul;76(3):244-7. doi: 10.1007/BF00283616.
9
Identification of a break-prone structure in the 9q1 heterochromatic region.9q1异染色质区域中一个易断裂结构的鉴定。
Hum Genet. 1991 Jan;86(3):261-4. doi: 10.1007/BF00202405.
10
Chromosome bands, their chromatin flavors, and their functional features.染色体带、它们的染色质特征及其功能特性。
Am J Hum Genet. 1992 Jul;51(1):17-37.
[Spontaneous chromosome aberrations in familial panmyelopathy].[家族性全髓病中的自发染色体畸变]
Humangenetik. 1964;1(2):194-6. doi: 10.1007/BF00389636.
5
Analysis of human metaphase chromosome set by aid of DNA-binding fluorescent agents.借助DNA结合荧光剂对人类中期染色体组进行分析。
Exp Cell Res. 1970 Oct;62(2):490-2. doi: 10.1016/0014-4827(70)90586-0.
6
Evidence for an inverse relationship between x-ray induced chromatid and chromosome breakage in human chromosomes.X射线诱导的人类染色体染色单体和染色体断裂之间存在负相关关系的证据。
Hereditas. 1973;75(2):259-65. doi: 10.1111/j.1601-5223.1973.tb01167.x.
7
Preferential location of x-ray induced chromosome breakage in the R-bands of human chromosomes.X射线诱导的染色体断裂在人类染色体R带中的优先定位。
Hereditas. 1973;74(1):57-67. doi: 10.1111/j.1601-5223.1973.tb01104.x.
8
High resolution studies on the pattern of induced exchanges in the human karyotype.关于人类染色体组中诱导交换模式的高分辨率研究。
Chromosoma. 1973;40(4):333-46. doi: 10.1007/BF00399426.
9
Radiation-induced non-random chromosome breakage.辐射诱导的非随机染色体断裂。
Exp Cell Res. 1972 Dec;75(2):541-3. doi: 10.1016/0014-4827(72)90469-7.
10
Giemsa technique for the detection of sister chromatid exchanges.用于检测姐妹染色单体交换的吉姆萨技术。
Chromosoma. 1974;48(4):355-60. doi: 10.1007/BF00290992.