• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression.

作者信息

Somjen G G

出版信息

Brain Res. 1984 Oct 8;311(1):186-8. doi: 10.1016/0006-8993(84)91416-1.

DOI:10.1016/0006-8993(84)91416-1
PMID:6488041
Abstract

Changes in the pH of interstitial fluid were measured with H+-selective double-barreled micropipette electrodes in fascia dentata of urethane-anesthetized rats. Paroxysmal afterdischarges provoked by repetitive stimulation of an afferent fiber tract brought in their wake acidification by 0.07 to 0.2 pH units. Spreading depression caused acidification by 0.2-0.5 pH units. Acid shifts were often preceded by transient alkalinization. Acidification is attributed to the production of CO2 and of other acid metabolites.

摘要

相似文献

1
Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression.
Brain Res. 1984 Oct 8;311(1):186-8. doi: 10.1016/0006-8993(84)91416-1.
2
Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression.在电刺激、癫痫放电和扩散性抑制期间，CA1区和齿状回的细胞外pH反应。
J Neurophysiol. 2000 Jun;83(6):3519-24. doi: 10.1152/jn.2000.83.6.3519.
3
Sustained potential shifts and paroxysmal discharges in hippocampal formation.海马结构中的持续电位变化和阵发性放电。
J Neurophysiol. 1985 Apr;53(4):1079-97. doi: 10.1152/jn.1985.53.4.1079.
4
Potassium and calcium concentrations in interstitial fluid of hippocampal formation during paroxysmal responses.阵发性反应期间海马结构间质液中的钾和钙浓度
J Neurophysiol. 1985 Apr;53(4):1098-108. doi: 10.1152/jn.1985.53.4.1098.
5
Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.大鼠海马结构中二氧化碳浓度、间质pH值与突触传递
J Physiol. 1988 Feb;396:247-66. doi: 10.1113/jphysiol.1988.sp016961.
6
Current source density of sustained potential shifts associated with electrographic seizures and with spreading depression in rat hippocampus.与大鼠海马区脑电图癫痫发作及扩散性抑制相关的持续性电位变化的电流源密度
Brain Res. 1992 Jan 20;570(1-2):85-91. doi: 10.1016/0006-8993(92)90567-s.
7
Extracellular pH changes and accompanying cation shifts during ouabain-induced spreading depression.哇巴因诱导的扩散性抑制过程中的细胞外pH变化及伴随的阳离子转移
J Neurophysiol. 2000 Mar;83(3):1338-45. doi: 10.1152/jn.2000.83.3.1338.
8
Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations.在一个纳入细胞间隙空间和离子浓度的神经元模型中模拟癫痫发作和扩散性抑制。
J Neurophysiol. 2000 Jul;84(1):495-512. doi: 10.1152/jn.2000.84.1.495.
9
Alkaline and acid transients in cerebellar microenvironment.小脑微环境中的碱性和酸性瞬变
J Neurophysiol. 1983 Mar;49(3):831-50. doi: 10.1152/jn.1983.49.3.831.
10
Interstitial volume changes during spreading depression (SD) and SD-like hypoxic depolarization in hippocampal tissue slices.海马组织切片中扩散性抑制（SD）和类SD缺氧去极化期间的间质容积变化。
J Neurophysiol. 1994 Jun;71(6):2548-51. doi: 10.1152/jn.1994.71.6.2548.

引用本文的文献

1
Mechanisms underlying modulation of human GlyRα3 by Zn and pH.锌和pH值对人甘氨酸受体α3亚基（GlyRα3）调节作用的潜在机制
Sci Adv. 2024 Dec 20;10(51):eadr5920. doi: 10.1126/sciadv.adr5920. Epub 2024 Dec 18.
2
A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia.一种危险的联系：脑缺血中的去极化扩散和组织酸化
J Cereb Blood Flow Metab. 2025 Feb;45(2):201-218. doi: 10.1177/0271678X241289756. Epub 2024 Nov 13.
3
A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level.
一种 pH 敏感的闭环纳米机器，可在单个神经元水平控制过度兴奋。
Nat Commun. 2024 Jul 4;15(1):5609. doi: 10.1038/s41467-024-49941-3.
4
Extracellular glutamate and GABA transients at the transition from interictal spiking to seizures.细胞外谷氨酸和 GABA 瞬变在发作间期棘波向癫痫发作的转变过程中。
Brain. 2024 Mar 1;147(3):1011-1024. doi: 10.1093/brain/awad336.
5
Hypothesis-generating analysis of the impact of non-damaging metabolic acidosis on the transcriptome of different cell types: Integrated stress response (ISR) modulation as general transcriptomic reaction to non-respiratory acidic stress?生成假说的分析：非损伤性代谢性酸中毒对不同细胞类型转录组的影响——整合应激反应（ISR）调节是否为非呼吸性酸性应激的普遍转录组反应？
PLoS One. 2023 Aug 25;18(8):e0290373. doi: 10.1371/journal.pone.0290373. eCollection 2023.
6
Triggering of Major Brain Disorders by Protons and ATP: The Role of ASICs and P2X Receptors.质子和 ATP 引发的主要脑部疾病：ASICs 和 P2X 受体的作用。
Neurosci Bull. 2023 May;39(5):845-862. doi: 10.1007/s12264-022-00986-8. Epub 2022 Nov 29.
7
Ketogenic Diet Alleviates Hippocampal Neurodegeneration Possibly via ASIC1a and the Mitochondria-Mediated Apoptotic Pathway in a Rat Model of Temporal Lobe Epilepsy.生酮饮食可能通过酸敏感离子通道1a（ASIC1a）和线粒体介导的凋亡途径减轻颞叶癫痫大鼠模型中的海马神经退行性变。
Neuropsychiatr Dis Treat. 2022 Sep 25;18:2181-2198. doi: 10.2147/NDT.S376979. eCollection 2022.
8
Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors.酸性 pH 值降低了斑马鱼 α1 和大鼠 α1β 重组甘氨酸受体对激动剂的功效和对突触样甘氨酸应用的反应。
J Physiol. 2022 Jan;600(2):333-347. doi: 10.1113/JP282171. Epub 2021 Dec 8.
9
Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling.大脑中酮体的作用超越能量代谢：从兴奋性到基因表达和细胞信号传导
Front Mol Neurosci. 2021 Aug 27;14:732120. doi: 10.3389/fnmol.2021.732120. eCollection 2021.
10
Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.肾上腺素能抑制有助于皮质扩散性去极化后细胞外钾的正常化。
Sci Rep. 2021 Apr 14;11(1):8150. doi: 10.1038/s41598-021-87609-w.