Wu S C, Secchi M B, Mancarella S, Fossa L, Bettazzi L, Oltrona L, Ciro A, Civelli M, Folli G
Cardiology. 1984;71(5):277-83. doi: 10.1159/000173676.
To investigate the usefulness of stress testing for the evaluation of hypertensive heart disease, 40 subjects, 28 men and 12 women (mean age 30.8 +/- 6.2 years), with mild or moderate hypertension, without ST segment or T wave abnormalities in their resting ECG, were examined. 13 patients (32.5%) showed exercise-induced ST segment depression. The heart rate at rest was significantly higher in the patients with a positive response; 6 of the 7 subjects with electrocardiographic signs of left ventricular hypertrophy (summed SV1 + maximum R V5/V6 voltage of 45 mm or more) had a positive exercise electrocardiographic test. There were no significant differences between positive and negative cases in age, sex, systolic and diastolic blood pressure, or the double product (heart rate X systolic pressure) at rest or during exercise. After resting blood pressure values had been significantly decreased by giving methyldopa with or without diuretics for at least 6 months, there were a regression of left ventricular hypertrophy in the resting ECG and an impressive reduction in the prevalence of exercise-positive responses (to 17.5%). In the 7 patients with positive exercise electrocardiographic tests even after antihypertensive treatment, no significant reduction in blood pressure values during exercise was obtained.
为研究应激试验在评估高血压性心脏病中的作用，对40名受试者进行了检查，其中男性28名，女性12名（平均年龄30.8±6.2岁），患有轻度或中度高血压，静息心电图无ST段或T波异常。13例患者（32.5%）出现运动诱发的ST段压低。反应阳性的患者静息心率显著更高；7例有左心室肥厚心电图征象（SV1总和+V5/V6最大R波电压45mm或更高）的受试者中，6例运动心电图试验呈阳性。阳性和阴性病例在年龄、性别、静息或运动时的收缩压和舒张压或双乘积（心率×收缩压）方面无显著差异。在使用甲基多巴联合或不联合利尿剂使静息血压值显著降低至少6个月后，静息心电图显示左心室肥厚有所消退，运动阳性反应的发生率显著降低（降至17.5%）。在7例即使经过抗高血压治疗运动心电图试验仍为阳性的患者中，运动期间血压值未显著降低。
