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去氧皮质酮盐(DOCA)高血压猪的主动脉僵硬度

Aortic stiffness in the DOCA-hypertensive pig.

作者信息

Walterhouse D O, Reinish L W, Mitchell J, Bohr D F

出版信息

Clin Physiol Biochem. 1984;2(4):146-53.

PMID:6488693
Abstract

Pulsatile changes in aortic diameter and pressure were monitored in order to obtain an index of aortic stiffness in the conscious pig during the development of mineralocorticoid hypertension. The aortic stiffness index increased but to a much lesser extent than it did in response to a similar pressure elevation produced by phenylephrine infusion. This observation suggests that chronic exposure to an elevated pulsatile pressure reduces the stiffness index at the elevated pressure.

摘要

在盐皮质激素性高血压发展过程中,对清醒猪的主动脉直径和压力的搏动性变化进行监测,以获得主动脉僵硬度指标。主动脉僵硬度指数增加,但程度远小于去氧肾上腺素输注引起的类似压力升高时的增加程度。这一观察结果表明,长期暴露于升高的搏动压力会降低升高压力下的僵硬度指数。

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