Levine M, Jones M W, Gribble M
Clin Pharm. 1984 Sep-Oct;3(5):505-9.
The effect of influenza vaccination on serum phenytoin concentration was studied in a group of long-term care patients with epilepsy. The subjects in this study were 15 men and 1 woman with a mean age of 76.7 years. All were white, receiving long-term phenytoin therapy for seizure disorders, on stable antiepileptic regimens for a minimum of eight weeks, and scheduled to receive an influenza vaccination. Baseline phenytoin concentrations were determined one or two days before vaccination. Subjects were vaccinated subcutaneously with 0.5 ml of an inactivated whole-virion trivalent influenza vaccine. Phenytoin therapy was maintained, and serum concentrations were determined on days 7 and 14 following the vaccination. Assays were performed with a standard enzyme immunoassay technique. No significant increases in mean serum phenytoin concentrations were observed on days 7 or 14 following vaccination. However, temporary increases of 46-170% occurred in four subjects, and in two of these subjects, the increases in serum phenytoin concentration could best be attributed to the influenza vaccination. Serum phenytoin concentrations may be temporarily increased in some individuals after influenza vaccination.
在一组患有癫痫的长期护理患者中研究了流感疫苗接种对血清苯妥英浓度的影响。本研究的受试者为15名男性和1名女性，平均年龄76.7岁。所有受试者均为白人，因癫痫发作接受长期苯妥英治疗，采用稳定的抗癫痫方案至少8周，并计划接种流感疫苗。在接种疫苗前1天或2天测定苯妥英的基线浓度。受试者皮下注射0.5ml灭活全病毒三价流感疫苗。维持苯妥英治疗，并在接种疫苗后的第7天和第14天测定血清浓度。采用标准酶免疫测定技术进行检测。接种疫苗后第7天或第14天，未观察到血清苯妥英平均浓度有显著升高。然而，4名受试者出现了46%-170%的暂时升高，其中2名受试者血清苯妥英浓度的升高最可能归因于流感疫苗接种。流感疫苗接种后，部分个体的血清苯妥英浓度可能会暂时升高。
