Chandrasekar P H, Rolston K V, Chokkavelu V, Le Frock J L, Kannangara D W
Chemotherapy. 1984;30(5):331-6. doi: 10.1159/000238289.
The efficacy of cefoxitin, mezlocillin, latamoxef and metronidazole in anaerobic lung infection was studied using a rabbit model. A mixture of Bacteroides fragilis, Peptococcus morbillorum, Eubacterium lentum and Fusobacterium nucleatum was inoculated transtracheally to produce infection within the lung. Mezlocillin was most effective, achieving bacteriologic cure in 5 out of 8 animals. With cefoxitin therapy, 4 out of 8 became bacteriologically sterile. Severe diarrhea with elevated titers of Clostridium difficile toxin was noted in most cefoxitin-treated animals. Latamoxef- and metronidazole-treated animals had apparently healed lesions, but cultures were positive in 6 and 7 out of 8 in each group, respectively. The commonest pathogen isolated in the last two groups was P. morbillorum. The therapeutic superiority of mezlocillin over metronidazole and latamoxef was statistically significant (p less than or equal to 0.05).
使用兔模型研究了头孢西丁、美洛西林、拉氧头孢和甲硝唑在厌氧性肺部感染中的疗效。将脆弱拟杆菌、麻疹消化球菌、迟缓真杆菌和具核梭杆菌的混合物经气管接种以在肺内产生感染。美洛西林最有效，8只动物中有5只实现了细菌学治愈。用头孢西丁治疗时，8只中有4只达到细菌学无菌。在大多数接受头孢西丁治疗的动物中观察到严重腹泻且艰难梭菌毒素滴度升高。接受拉氧头孢和甲硝唑治疗的动物病变明显愈合，但每组8只动物中分别有6只和7只培养呈阳性。后两组中分离出的最常见病原体是麻疹消化球菌。美洛西林在治疗上优于甲硝唑和拉氧头孢，具有统计学意义（p小于或等于0.05）。
