Lopez L M, Gefter M L, Hemmes R J
Drug Intell Clin Pharm. 1984 Oct;18(10):812-5. doi: 10.1177/106002808401801008.
Twenty patients with essential hypertension, who were receiving a diuretic plus propranolol qid, were instructed to take their entire daily requirement of propranolol as a single morning dose. Blood pressure was measured in standing and supine positions at the end of a dosing interval. Patients were questioned about the occurrence of specific propranolol side effects during each of four bi-weekly evaluations. Mean blood pressure on once-daily propranolol did not differ significantly from that observed on propranolol qid. Daily doses of propranolol ranged from 80-320 mg. Side effects were infrequent and mild. We conclude that propranolol may be administered as a single daily dose to patients with hypertension whose blood pressure already has been controlled on a qid regimen.
二十名原发性高血压患者正在接受利尿剂加普萘洛尔每日四次的治疗，他们被要求将每日所需的全部普萘洛尔作为单次晨起剂量服用。在给药间隔结束时测量患者站立位和仰卧位的血压。在每两周一次的四次评估中，询问患者关于特定普萘洛尔副作用的发生情况。每日一次服用普萘洛尔时的平均血压与每日四次服用普萘洛尔时观察到的血压无显著差异。普萘洛尔的日剂量范围为80 - 320毫克。副作用很少且轻微。我们得出结论，对于血压已通过每日四次治疗方案得到控制的高血压患者，普萘洛尔可以每日单次给药。
