Mann S, Craig M W, Balasubramanian V, Raftery E B
Br J Clin Pharmacol. 1980 Nov;10(5):443-7. doi: 10.1111/j.1365-2125.1980.tb01786.x.
1 The technique of continuous recording of intra-arterial blood pressure in ambulant hypertensives has been used to investigate the effects of a long-acting formulation of propranolol (propranolol LA). 2 Seven subjects with untreated essential hypertension were studied before and 2 months after commencing treatment with propranolol LA once daily in the morning, results showing that smooth control of blood pressure and heart rate occurred throughout 24 h. 3 Bicycle ergometry tests performed by these subjects during both studies showed significant blood pressure reduction by propranolol LA during the mild and moderate grades of dynamic exercise. 4 In a parallel study where six treated hypertensives were monitored before and after substitution of standard propranolol by the 'LA' form, close correspondence of blood pressure throughout the 24 h occurred with each regimen.
动态血压监测技术已被用于研究长效普萘洛尔（propranolol LA）对高血压患者的影响。
七名未经治疗的原发性高血压患者在开始每天早晨服用一次propranolol LA治疗前及治疗2个月后接受了研究，结果显示血压和心率在24小时内得到了平稳控制。
这些受试者在两项研究期间进行的自行车测力计测试表明，在轻度和中度动态运动期间，propranolol LA可显著降低血压。
在一项平行研究中，六名接受治疗的高血压患者在改用“LA”型普萘洛尔替代标准普萘洛尔前后接受了监测，两种治疗方案在24小时内的血压情况密切相关。
