Picciano J C, DiNardo J C, Schnetzinger R W, Morris W E, Wolf B A
Drug Chem Toxicol. 1984;7(4):397-405. doi: 10.3109/01480548408998266.
The oxidative dye 4-methyl-N-ethylamino phenol sulfate was evaluated for teratogenic potential. The dye was administered by gavage to pregnant Sprague-Dawley rats at dose levels of 300, 600, and 1200 mg/kg on gestation days six through fifteen. No signs of toxicity were observed during the treatment period. A significant reduction in mean maternal weight gain was noted during treatment at the high dose level of 1200 mg/kg. The test material did not produce embryotoxic nor fetal toxic effects at dose levels utilized. Evaluation of fetal external, visceral, and skeletal anomalies revealed no statistically significant differences between dye treated and control groups. Oral exposure of dams to the positive control, Vitamin A, resulted in a significant increase in the number of litters with abnormal fetuses.
对氧化染料硫酸4-甲基-N-乙基氨基酚的致畸潜力进行了评估。在妊娠第6至15天，通过灌胃法将该染料以300、600和1200mg/kg的剂量给予怀孕的Sprague-Dawley大鼠。在治疗期间未观察到毒性迹象。在1200mg/kg的高剂量水平治疗期间，观察到母体平均体重增加显著降低。在所使用的剂量水平下，受试物质未产生胚胎毒性或胎儿毒性作用。对胎儿外观、内脏和骨骼异常的评估显示，染料处理组和对照组之间无统计学上的显著差异。母鼠口服阳性对照物维生素A后，有异常胎儿的窝数显著增加。
