Shekhter-Levin S, Amato D, Axelrad A A
Exp Hematol. 1984 Sep;12(8):650-4.
We have investigated the proliferative behavior of early erythropoietic progenitor cells (BFU-E) in human umbilical cord blood with hydroxyurea and tritiated-thymidine suicide experiments. Our results indicate that the great majority of these progenitors are normally either in a quiescent state with respect to DNA synthesis or in a prolonged cell cycle experimentally indistinguishable from this state. In this regard, neonatal BFU-E resemble adult circulating BFU-E.
我们通过羟基脲和氚标记胸腺嘧啶核苷自杀实验，研究了人脐带血中早期红细胞生成祖细胞（爆式红系集落形成单位，BFU-E）的增殖行为。我们的结果表明，这些祖细胞中的绝大多数在DNA合成方面通常处于静止状态，或者处于实验上与该状态无法区分的延长细胞周期中。在这方面，新生儿BFU-E类似于成人循环中的BFU-E。
