Mendizábal A F, Quiroga S, Farinati Z, Lahoz M, Nagle C
Fertil Steril. 1984 Nov;42(5):737-40. doi: 10.1016/s0015-0282(16)48199-9.
The usefulness of the direct 4-hour radioimmunoassay of estriol-16-glucuronide (E3G) and pregnanediol-3-glucuronide (P2G) in first morning urine (FMU) for establishing a prognosis of the early pregnancy outcome was evaluated in 106 patients that became pregnant. Microaliquots of FMU were serially assayed from day 3 of the conception cycle until day 80 of pregnancy. The E3G and P2G profiles of 19 pregnancies which terminated in spontaneous abortion with either a diagnosis of the blighted ovum syndrome (n = 11) or presumption of a corpus luteum/trophoblast failure (n = 8) have been compared with those of clinically normal pregnancies (n = 87). Normal pregnancies displayed typical patterns of E3G and P2G development, while variations were observed in abortive events that reflected changes of the fetoplacental unit.
对106例妊娠患者进行了研究，评估晨尿中雌三醇-16-葡萄糖醛酸苷（E3G）和孕二醇-3-葡萄糖醛酸苷（P2G）的直接4小时放射免疫测定法对早期妊娠结局预后判断的有用性。从受孕周期第3天至妊娠第80天对晨尿微量样本进行连续检测。将19例诊断为枯萎卵综合征（n = 11）或推测为黄体/滋养层功能不全（n = 8）而自然流产的妊娠的E3G和P2G曲线与临床正常妊娠（n = 87）的曲线进行了比较。正常妊娠呈现典型的E3G和P2G发育模式，而流产事件中观察到的变化反映了胎儿-胎盘单位的改变。
