浸润移植的化学诱导大鼠肉瘤的细胞毒性效应细胞的表型。
Phenotype of cytotoxic effector cells infiltrating a transplanted, chemically induced rat sarcoma.
作者信息
Ferry B L, Flannery G R, Robins R A, Lawry J, Baldwin R W
出版信息
Immunology. 1984 Oct;53(2):243-50.
Previous work from this laboratory indicated that methylcholanthrene-induced sarcomas in the rat are infiltrated by cells with the cytotoxic properties of natural killer (NK) cells. Using a combination of velocity sedimentation and analysis and separation in the fluorescence-activated cell sorter, it has been possible to isolate and characterize these putative NK cells. The present results confirm that cytotoxicity is restricted to NK-sensitive targets (syngeneic, allogeneic and xenogeneic) and no evidence was found for cytotoxic T lymphocytes (CTL). In addition, effector cells have the morphology of large granular lymphocytes, and the pattern of expression of five monoclonal antibody-defined surface markers is identical with that of normal splenic NK cells.
该实验室之前的研究表明，甲基胆蒽诱导的大鼠肉瘤被具有自然杀伤（NK）细胞细胞毒性特性的细胞浸润。通过速度沉降以及在荧光激活细胞分选仪中进行分析和分离相结合的方法，已能够分离并鉴定这些假定的NK细胞。目前的结果证实，细胞毒性仅限于对NK敏感的靶标（同基因、异基因和异种），未发现细胞毒性T淋巴细胞（CTL）的证据。此外，效应细胞具有大颗粒淋巴细胞的形态，并且五种单克隆抗体定义的表面标志物的表达模式与正常脾NK细胞相同。
Zotero 插件