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浸润移植的化学诱导大鼠肉瘤的细胞毒性效应细胞的表型。

Phenotype of cytotoxic effector cells infiltrating a transplanted, chemically induced rat sarcoma.

作者信息

Ferry B L, Flannery G R, Robins R A, Lawry J, Baldwin R W

出版信息

Immunology. 1984 Oct;53(2):243-50.

PMID:6490084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454825/
Abstract

Previous work from this laboratory indicated that methylcholanthrene-induced sarcomas in the rat are infiltrated by cells with the cytotoxic properties of natural killer (NK) cells. Using a combination of velocity sedimentation and analysis and separation in the fluorescence-activated cell sorter, it has been possible to isolate and characterize these putative NK cells. The present results confirm that cytotoxicity is restricted to NK-sensitive targets (syngeneic, allogeneic and xenogeneic) and no evidence was found for cytotoxic T lymphocytes (CTL). In addition, effector cells have the morphology of large granular lymphocytes, and the pattern of expression of five monoclonal antibody-defined surface markers is identical with that of normal splenic NK cells.

摘要

该实验室之前的研究表明，甲基胆蒽诱导的大鼠肉瘤被具有自然杀伤（NK）细胞细胞毒性特性的细胞浸润。通过速度沉降以及在荧光激活细胞分选仪中进行分析和分离相结合的方法，已能够分离并鉴定这些假定的NK细胞。目前的结果证实，细胞毒性仅限于对NK敏感的靶标（同基因、异基因和异种），未发现细胞毒性T淋巴细胞（CTL）的证据。此外，效应细胞具有大颗粒淋巴细胞的形态，并且五种单克隆抗体定义的表面标志物的表达模式与正常脾NK细胞相同。

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Phenotype of cytotoxic effector cells infiltrating a transplanted, chemically induced rat sarcoma.浸润移植的化学诱导大鼠肉瘤的细胞毒性效应细胞的表型。
Immunology. 1984 Oct;53(2):243-50.
2
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引用本文的文献

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Jpn J Cancer Res. 1991 Nov;82(11):1292-8. doi: 10.1111/j.1349-7006.1991.tb01795.x.

本文引用的文献

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The specificity of rat natural killer cells and cytotoxic macrophages on solid tumor-derived target cells and selected variants.大鼠自然杀伤细胞和细胞毒性巨噬细胞对实体瘤衍生靶细胞及选定变体的特异性。
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Natural killer cells infiltrate transplanted chemically induced sarcomas.自然杀伤细胞浸润化学诱导的移植肉瘤。
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The induction of cytotoxic macrophages and natural killer cells in congenitally athymic rnu/rnu rats.先天性无胸腺rnu/rnu大鼠中细胞毒性巨噬细胞和自然杀伤细胞的诱导。
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Natural killer activity in the rat. II. Analysis of surface antigens on LGL by flow cytometry.大鼠的自然杀伤活性。II. 利用流式细胞术分析大颗粒淋巴细胞表面抗原
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Monoclonal antibodies which distinguish between human NK cells and cytotoxic T lymphocytes.可区分人自然杀伤细胞和细胞毒性T淋巴细胞的单克隆抗体。
Nature. 1980 Nov 27;288(5789):394-6. doi: 10.1038/288394a0.
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Two subsets of rat T lymphocytes defined with monoclonal antibodies.用单克隆抗体定义的大鼠T淋巴细胞的两个亚群。
Eur J Immunol. 1980 Aug;10(8):609-15. doi: 10.1002/eji.1830100807.
8
The roles of host and donor cells in the rejection of skin allografts by T cell-deprived rats injected with syngeneic T cells.宿主细胞和供体细胞在注射同基因T细胞的T细胞缺失大鼠皮肤同种异体移植排斥反应中的作用。
Eur J Immunol. 1982 Jun;12(6):511-8. doi: 10.1002/eji.1830120612.
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Role of T-lymphocyte subsets in tumor rejection: implications for developing biological response modifiers and monitoring tumor--host interactions during tumor development.T淋巴细胞亚群在肿瘤排斥反应中的作用：对开发生物反应调节剂及监测肿瘤发生过程中肿瘤与宿主相互作用的意义。
J Biol Response Mod. 1983;2(2):101-9.
10
Reversible induction of natural killer cell activity in cloned murine cytotoxic T lymphocytes.克隆化小鼠细胞毒性T淋巴细胞中自然杀伤细胞活性的可逆诱导
Nature. 1983;305(5930):155-8. doi: 10.1038/305155a0.