用标记大鼠淋巴细胞亚群的单克隆抗体所定义的大鼠自然杀伤细胞的表型。
Phenotype of rat natural killer cells defined by monoclonal antibodies marking rat lymphocyte subsets.
作者信息
Cantrell D A, Robins R A, Brooks C G, Baldwin R W
出版信息
Immunology. 1982 Jan;45(1):97-103.
Abstract
The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate rat spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK) activity in a quantifiable 6 hr 51Cr release assay. The data establish that rat natural killer cells are heterogeneous with respect to their surface antigen expression and that subpopulations of rat NK cells express the OX8 and W3/13 defined antigens. However, rat NK cells do not express the antigen defined by W3/24 monoclonal antibody.
摘要
采用荧光激活细胞分选仪和玫瑰花结去除技术，将大鼠脾脏淋巴细胞和卡介苗激活的淋巴细胞分离为表达和不表达由W3/13、W3/23和OX8单克隆抗体所定义抗原的亚群。然后，在可定量的6小时51Cr释放试验中检测所得亚群的自然杀伤（NK）活性。数据表明，大鼠自然杀伤细胞在表面抗原表达方面具有异质性，并且大鼠NK细胞亚群表达OX8和W3/13所定义的抗原。然而，大鼠NK细胞不表达由W3/24单克隆抗体所定义的抗原。
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