Fanciullacci M, Pietrini U, Marabini S, Boccuni M, Sicuteri F
Int J Clin Pharmacol Res. 1984;4(3):247-52.
A pupillometric study was performed to evaluate the mydriatic response to tyramine, a noradrenaline releaser. There were three groups of subjects: (a) 10 cluster headache patients, in an asymptomatic period; (b) 20 of their close relatives, exempt from this disease; (c) 10 healthy controls. The tyramine was instilled into both eyes of each subject. The controls displayed an isocoric tyramine-induced mydriasis but the cluster headache sufferers and their relatives showed an anisocoric mydriasis. This anisocoric mydriasis was caused by a deficient mydriatic response on one side, which in the cluster patients corresponded to the symptomatic side. The sympathetic abnormality of the iris may be the expression of a functional asymmetry in the hypothalamus. Central sympathetic asymmetry could thus represent a dysgenetic family predisposition to lateralized headache attacks.
进行了一项瞳孔测量研究，以评估对去甲肾上腺素释放剂酪胺的散瞳反应。研究对象分为三组：(a) 10名处于无症状期的丛集性头痛患者；(b) 20名未患此病的近亲；(c) 10名健康对照者。将酪胺滴入每位受试者的双眼。对照组表现出等瞳孔的酪胺诱导散瞳，而丛集性头痛患者及其亲属则表现出不等瞳孔散瞳。这种不等瞳孔散瞳是由一侧散瞳反应不足引起的，在丛集性头痛患者中，这一侧对应于症状侧。虹膜的交感神经异常可能是下丘脑功能不对称的表现。因此，中枢交感神经不对称可能代表了家族性发育异常对偏侧性头痛发作的易感性。
