Boccuni M, Morace G, Pietrini U, Porciani M C, Fanciullacci M, Sicuteri F
Cephalalgia. 1984 Mar;4(1):9-15. doi: 10.1046/j.1468-2982.1984.0401009.x.
Ten cluster headache patients and 10 healthy controls were subjected to electrocardiographic and pupillometric procedures in a search for cardiac and pupillary sympathergic asymmetry. Sympathergic stimulation was provoked by hyperventilation and by instilling tyramine into both eyes. In the control group, hyperventilation changed neither the T-wave form and polarity nor the QTc. Tyramine provoked an equal mydriasis on the two sides. In cluster headache sufferers, hyperventilation produced changes in the T-wave form and polarity as well as an increase of the QTc due to a disproportionate shortening of the R-R and Q-T intervals. An unequal mydriasis was noted after tyramine instillation due to less marked response on the symptomatic side. The observed electrocardiographic abnormalities are considered an expression of an asynchronous repolarization attributed to a sympathergic asymmetry. It is postulated that both the cardiac and pupillary sympathetic imbalance associated with cluster headache are central in origin.
对10名丛集性头痛患者和10名健康对照者进行了心电图和瞳孔测量程序,以寻找心脏和瞳孔交感神经不对称性。通过过度通气和向双眼滴注酪胺来激发交感神经刺激。在对照组中,过度通气既未改变T波形态和极性,也未改变QTc。酪胺引起双侧瞳孔散大程度相同。在丛集性头痛患者中,过度通气导致T波形态和极性改变,以及由于R-R和Q-T间期不成比例缩短导致QTc增加。滴注酪胺后,由于症状侧反应不明显,出现不等大瞳孔散大。观察到的心电图异常被认为是交感神经不对称导致的复极不同步的表现。据推测,与丛集性头痛相关的心脏和瞳孔交感神经失衡均起源于中枢。