Isbister J P
Int J Microcirc Clin Exp. 1984;3(2):93-108.
There is a wide range of disorders in which plasma volume may be contracted. This may either be due to a primary reduction in plasma volume, or secondary to a reduction in the volume of the vascular compartment. In the former there may be a salt and water deficit as the cause or a loss of plasma volume due to a capillary leak. Reduction of the vascular compartment is usually due to increased adrenergic activity reducing the circulatory capacitance volume. Plasma volume is reduced to compensate for the overfilling of the central circulation. The causes and clinical significance of plasma volume contraction are discussed, with particular emphasis on the pathophysiology and implications for therapy. The controversial subject of stress polycythaemia is addressed and a theoretical analysis of its pathophysiology presented.
存在多种血浆容量可能收缩的病症。这可能是由于血浆容量的原发性减少，或者是继发于血管腔室容量的减少。在前者中，可能存在盐和水缺乏作为原因，或者由于毛细血管渗漏导致血浆容量丧失。血管腔室的减少通常是由于肾上腺素能活性增加，减少了循环血容量。血浆容量减少以补偿中心循环的过度充盈。讨论了血浆容量收缩的原因和临床意义，特别强调了其病理生理学及对治疗的影响。探讨了应激性红细胞增多症这一有争议的主题，并对其病理生理学进行了理论分析。
