Graves J A, McMillan J
J Cell Physiol. 1984 Nov;121(2):409-14. doi: 10.1002/jcp.1041210219.
To test the hypothesis that the duration of DNA synthesis is an inverse function of nuclear size or DNA content, the S phase was calculated from PLM analysis for pseudodiploid, tetraploid, and octaploid lines of Chinese hamster cells growing as a monolayer or in suspension. S phase times were found not to be significantly different between polyploid lines and the diploid lines from which they were derived, regardless of the conformation of the nucleus. There is no evidence, therefore, that would implicate the nuclear membrane, or nuclear surface area/volume relationships, in the control of DNA synthesis.
为了验证DNA合成持续时间是细胞核大小或DNA含量的反函数这一假设，我们通过PLM分析计算了单层生长或悬浮生长的中国仓鼠细胞的假二倍体、四倍体和八倍体品系的S期。结果发现，多倍体品系与其来源的二倍体品系之间的S期时间没有显著差异，无论细胞核的形态如何。因此，没有证据表明细胞核膜或核表面积/体积关系参与了DNA合成的调控。
