Deitch J S, Rubel E W
J Comp Neurol. 1984 Oct 10;229(1):66-79. doi: 10.1002/cne.902290106.
The time course and specificity of the changes in dendritic morphology following deafferentation were examined in nucleus laminaris of young chickens. The dendrites of nucleus laminaris neurons are segregated into dorsal and ventral domains, which are innervated separately from the ipsilateral and contralateral nucleus magnocellularis, respectively. Transection of the crossed dorsal cochlear tract deafferents the ventral dendrites of nucleus laminaris bilaterally without interrupting the matching input to the dorsal dendrites. In 10-day-old chicks, atrophy of the ventral dendrites began immediately after transecting the tract; the ventral dendrites were 10% shorter by 1 hour and 16% shorter by 2 hours after deafferentation. The length of the ventral dendrites progressively decreased over the next 2 weeks, resulting in at least a 60% loss of ventral dendrite 16 days after surgery. The dorsal dendrites of the same cells, whose afferents remained intact, did not change in length during the time course of this study. However, 16 days after the lesion, spines appeared on the normally smooth dorsal and ventral dendrites. The time course of dendritic atrophy and its restriction to the deafferented postsynaptic surface are related to possible mechanisms by which afferents regulate and maintain their target neurons.
在幼鸡的层状核中，研究了去传入神经支配后树突形态变化的时间进程和特异性。层状核神经元的树突分为背侧和腹侧区域，分别由同侧和对侧大细胞核单独支配。切断交叉的背侧耳蜗束会使双侧层状核的腹侧树突失去传入神经支配，而不会中断对背侧树突的匹配输入。在10日龄雏鸡中，切断该束后腹侧树突立即开始萎缩；去传入神经支配后1小时，腹侧树突缩短10%，2小时后缩短16%。在接下来的2周内，腹侧树突的长度逐渐减少，术后16天腹侧树突至少损失60%。在本研究的时间进程中，同一细胞的背侧树突传入神经保持完整，其长度没有变化。然而，损伤后16天，在正常光滑的背侧和腹侧树突上出现了棘突。树突萎缩的时间进程及其对去传入神经支配的突触后表面的限制与传入神经调节和维持其靶神经元的可能机制有关。
