van Uffelen R, van Saene H K, Fidler V, Löwenberg A
Intensive Care Med. 1984;10(5):233-7. doi: 10.1007/BF00256259.
During 1 year 27 patients admitted to the respiratory intensive care unit were monitored bacteriologically for a minimum of 10 days (mean: 26.7 days). Oropharyngeal swabs and tracheal aspirates were qualitatively and semi-quantitatively cultured twice weekly. A correlation between oropharyngeal and tracheal flora was found: once a bacterial species colonized the oropharyngeal cavity in high numbers, the identical microorganism was frequently isolated (greater than 50%) from the lower respiratory tract. Six of the 27 patients acquired an infection of the lower airways in the respiratory intensive care unit. The bacteria involved belonged to the patients oropharyngeal flora: S. aureus, Enterobacteriaceae and Pseudomonadaceae. As a result of this study showing the oropharynx to be the source of lower airway colonization/infection, a policy for infection prevention has been outlined. This policy is based on the concept of source elimination by means of oropharyngeal decontamination.
在1年的时间里，对入住呼吸重症监护病房的27例患者进行了至少10天（平均26.7天）的细菌学监测。每周两次对口咽拭子和气管吸出物进行定性和半定量培养。发现口咽部和气管菌群之间存在相关性：一旦一种细菌在口咽腔大量定植，相同的微生物就经常（超过50%）在下呼吸道被分离出来。27例患者中有6例在呼吸重症监护病房发生了下呼吸道感染。所涉及的细菌属于患者的口咽菌群：金黄色葡萄球菌、肠杆菌科和假单胞菌科。这项研究表明口咽部是下呼吸道定植/感染的来源，因此制定了一项感染预防政策。该政策基于通过口咽去污消除源头的理念。
