异烟肼的致突变性：对小鼠胚胎体细胞染色体畸变的检测
Mutagenicity of isoniazid: testing for somatic chromosome aberrations in mouse embryos.
作者信息
Fränz J
出版信息
Hum Genet. 1978 May 16;42(1):28-30. doi: 10.1007/BF00291620.
PMID:649164
Abstract
Isonicotinic acid hydrazide (INH) were given by peroral intubation to pregnant mice of strain C57BL/6Ffm on day 9 of pregnancy, INH was given in the following doses: 0, 5, 25, and 125 mg/kg solved in physiological saline. Cytogenetic analysis of homogenized embryos 6, 12, 24, and 48 h, resp., after treatment of the females did not show any increase of the rate of gaps or chromosomal aberrations.
摘要
在妊娠第9天，通过经口插管给C57BL/6Ffm品系的怀孕小鼠给予异烟肼（INH），异烟肼以以下剂量溶于生理盐水中给予：0、5、25和125mg/kg。在雌性小鼠接受处理后，分别在6、12、24和48小时对匀浆胚胎进行细胞遗传学分析，结果未显示间隙率或染色体畸变率有任何增加。
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