异烟肼（INH）对中国仓鼠和小鼠精原细胞的影响。
The effect of isoniazid (INH) on Chinese hamster and mouse spermatogonia.
作者信息
Miltenburger H G, Träger H, Adler I D, Schmaltz A, Rathenberg R, Schwegler H, Pawlowitzki I H, Nautsch C, Müller D
出版信息
Hum Genet. 1978 May 16;42(1):44-9. doi: 10.1007/BF00291622.
Acute and chronic treatment of Chinese hamsters and mice with 5, 25 and 125 mg/kg isoniazid (INH) given by oral intubation did not enhance the chromosomal aberration frequencies in spermatogonia. The structural and numerical aberration rates remained in the range of spontaneous events even after the chronic treatment over 12 weeks with 3 x 125 mg/kg INH per week. This dose is much higher than normally used for prevention and therapy in man (3--16 mg/kg).
通过口服插管对中国仓鼠和小鼠分别给予5、25和125mg/kg的异烟肼（INH）进行急性和慢性治疗，并未提高精原细胞中的染色体畸变频率。即使在每周用3×125mg/kg INH进行超过12周的慢性治疗后，结构和数目畸变率仍保持在自发事件的范围内。该剂量远高于人类预防和治疗中通常使用的剂量（3-16mg/kg）。
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