Miltenburger H G, Singh J R, Barth B M
Hum Genet. 1980;54(1):93-6. doi: 10.1007/BF00279055.
X-irradiation of Chinese hamsters with 50 and 200 rad delayed the centromere separation of bone marrow chromosomes. Combination of a treatment with 13.3 mg cyclophosphosphamide/kg body wt. and 50 rad did not result in an enhanced effect compared with the single treatments. Again, the separation sequence was not influenced. No delay was induced by a treatment with 125 mg isoniazid/kg, but a slightly and significantly earlier separation of the chromatids in both groups of metacentric and acrocentric chromosomes occurred. The separation delay seen after irradiation with 50 rad disappeared when the animals were pretreated with isoniazid. Independently of these results the asynchronous separation sequence was not altered in any of the experiments.
用50拉德和200拉德的X射线照射中国仓鼠，会延迟骨髓染色体着丝粒的分离。每千克体重使用13.3毫克环磷酰胺与50拉德的联合处理，与单一处理相比，并未产生增强效应。而且，分离顺序未受影响。每千克体重使用125毫克异烟肼处理并未导致延迟，但两组中着丝粒染色体和近端着丝粒染色体的染色单体分离均略有提前且差异显著。当动物用异烟肼预处理后，50拉德照射后出现的分离延迟消失。无论这些结果如何，异步分离顺序在任何实验中均未改变。
