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毛细管柱气相色谱法测定人血浆中5-单硝酸异山梨酯

Determination of isosorbide 5-mononitrate in human plasma by capillary column gas chromatography.

作者信息

Straehl P, Galeazzi R L

出版信息

J Pharm Sci. 1984 Sep;73(9):1317-9. doi: 10.1002/jps.2600730938.

DOI:10.1002/jps.2600730938
PMID:6491964
Abstract

An electron-capture gas chromatographic method for the determination of isosorbide 5-mononitrate in human plasma using a capillary column is described. Isosorbide 5-mononitrate and the internal standard (isosorbide dinitrate) are extracted from the alkalinized plasma with ether. The lower limit of detection for isosorbide 5-mononitrate is 1 ng/mL of plasma.

摘要

本文描述了一种使用毛细管柱测定人血浆中5-单硝酸异山梨酯的电子捕获气相色谱法。5-单硝酸异山梨酯和内标物（二硝酸异山梨酯）从碱化血浆中用乙醚萃取。5-单硝酸异山梨酯的检测下限为血浆1 ng/mL。

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