Levy G, Houston J B
Pediatrics. 1976 Sep;58(3):432-5.
Acetaminophen intoxication can cause hepatic, renal, and myocardial necrosis which is often fatal. These lesions develop very rapidly, perhaps during the first pass of the drug through the liver. In case of acute ingestion of an overdose it is therefore essential to employ measures for reducing the absorption of acetaminophen. The effect of activated charcoal on acetaminophen absorption by normal volunteers was determined as a function of the dose of charcoal, the dosage form of acetaminophen, and the charcoal-to-acetaminophen dose ratio. The results indicate that activated charcoal can be an effective antidote for acute acetaminophen intoxication, if administered promptly and in sufficient quantity.
对乙酰氨基酚中毒可导致肝、肾和心肌坏死，往往是致命的。这些损伤发展非常迅速，可能在药物首次通过肝脏时就发生了。因此，在急性过量摄入的情况下，采取措施减少对乙酰氨基酚的吸收至关重要。研究了活性炭对正常志愿者对乙酰氨基酚吸收的影响，该影响是活性炭剂量、对乙酰氨基酚剂型以及活性炭与对乙酰氨基酚剂量比的函数。结果表明，如果及时给予足够量的活性炭，它可以成为急性对乙酰氨基酚中毒的有效解毒剂。
