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呼肠孤病毒3型基因组片段S4：编码一种主要病毒体表面蛋白的基因的核苷酸序列

Reovirus type 3 genome segment S4: nucleotide sequence of the gene encoding a major virion surface protein.

作者信息

Giantini M, Seliger L S, Furuichi Y, Shatkin A J

出版信息

J Virol. 1984 Dec;52(3):984-7. doi: 10.1128/JVI.52.3.984-987.1984.

DOI:10.1128/JVI.52.3.984-987.1984
PMID:6492267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254625/
Abstract

A full-length cDNA copy of reovirus double-stranded RNA genome segment S4 which codes for a major virion structural polypeptide, sigma 3, has been completely sequenced. The 1,196-nucleotide cDNA contains a single long open reading frame in the plus strand extending 1,095 nucleotides from the 5'-proximal A-T-G to a single stop codon. This corresponds to translation of 92% of the S4 gene. The inferred sigma 3 polypeptide is hydrophilic and consists of 365 amino acids, totalling 41,164 daltons.

摘要

编码主要病毒体结构多肽σ3的呼肠孤病毒双链RNA基因组片段S4的全长cDNA拷贝已被完全测序。这个1196个核苷酸的cDNA在正链中包含一个单一的长开放阅读框，从5'近端的A-T-G延伸1095个核苷酸至一个单一的终止密码子。这相当于S4基因92%的翻译。推断的σ3多肽是亲水性的，由365个氨基酸组成，总计41164道尔顿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/254625/093c636046dc/jvirol00129-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/254625/093c636046dc/jvirol00129-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/254625/093c636046dc/jvirol00129-0271-a.jpg

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本文引用的文献

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Assignment of reovirus mRNA ribosome binding sites to virion genome segments by nucleotide sequence analyses.通过核苷酸序列分析将呼肠孤病毒mRNA核糖体结合位点定位到病毒粒子基因组片段上。
Nucleic Acids Res. 1980 Jan 25;8(2):337-50. doi: 10.1093/nar/8.2.337.
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A simple method for displaying the hydropathic character of a protein.一种展示蛋白质亲水性特征的简单方法。
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Reovirus transcriptase and capping enzymes are active in intact virions.呼肠孤病毒转录酶和加帽酶在完整病毒粒子中具有活性。
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The reovirus S4 gene 3' nontranslated region contains a translational operator sequence.呼肠孤病毒S4基因3'非翻译区包含一个翻译操纵序列。
J Virol. 2001 Jul;75(14):6517-26. doi: 10.1128/JVI.75.14.6517-6526.2001.
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Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3.呼肠孤病毒在蛋白酶抑制剂E64存在的情况下生长的适应性与病毒外衣壳蛋白sigma3羧基末端的一个突变相关。
J Virol. 2001 Apr;75(7):3197-206. doi: 10.1128/JVI.75.7.3197-3206.2001.
6
Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.在持续的呼肠孤病毒感染过程中选择的突变细胞不表达成熟的组织蛋白酶L，也不支持呼肠孤病毒的解体。
J Virol. 1999 Nov;73(11):9532-43. doi: 10.1128/JVI.73.11.9532-9543.1999.
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The reovirus mutant tsA279 L2 gene is associated with generation of a spikeless core particle: implications for capsid assembly.呼肠孤病毒突变体tsA279 L2基因与无刺核心颗粒的产生有关：对衣壳组装的影响。
J Virol. 1999 Mar;73(3):2298-308. doi: 10.1128/JVI.73.3.2298-2308.1999.
8
Identification of signals required for the insertion of heterologous genome segments into the reovirus genome.鉴定将异源基因组片段插入呼肠孤病毒基因组所需的信号。
Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12362-6. doi: 10.1073/pnas.92.26.12362.
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Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.病毒编码蛋白酶的表达：与细胞酶的功能和结构相似性
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The reovirus M1 gene determines the relative capacity of growth of reovirus in cultured bovine aortic endothelial cells.呼肠孤病毒M1基因决定了呼肠孤病毒在培养的牛主动脉内皮细胞中的相对生长能力。
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Role of the S4 gene in the establishment of persistent reovirus infection in L cells.S4基因在L细胞中建立呼肠孤病毒持续感染过程中的作用。
Cell. 1982 Mar;28(3):605-12. doi: 10.1016/0092-8674(82)90215-x.
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Cloning the double-stranded RNA genes of reovirus: sequence of the cloned S2 gene.呼肠孤病毒双链RNA基因的克隆：克隆的S2基因序列
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Sequence at both termini of the 10 genes of reovirus serotype 3 (strain Dearing).呼肠孤病毒3型（迪林株）10个基因两端的序列
Virology. 1982 Sep;121(2):307-19. doi: 10.1016/0042-6822(82)90170-2.
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Nucleic Acids Res. 1984 Jan 25;12(2):857-72. doi: 10.1093/nar/12.2.857.
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Two initiation sites detected in the small s1 species of reovirus mRNA by dipeptide synthesis in vitro.通过体外二肽合成在呼肠孤病毒mRNA的小s1种类中检测到两个起始位点。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1084-8. doi: 10.1073/pnas.81.4.1084.
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mRNA discrimination in extracts from uninfected and reovirus-infected L-cells.未感染和呼肠孤病毒感染的L细胞提取物中的mRNA鉴别
J Virol. 1984 Jul;51(1):215-22. doi: 10.1128/JVI.51.1.215-222.1984.
10
Nucleotide sequence of reovirus genome segment S3, encoding non-structural protein sigma NS.呼肠孤病毒基因组S3片段的核苷酸序列，编码非结构蛋白σNS。
Nucleic Acids Res. 1983 Sep 24;11(18):6399-408. doi: 10.1093/nar/11.18.6399.