Aleksandrova G M, Rozhkova V N, Borisova L N
Farmakol Toksikol. 1981 Jul-Aug;44(4):450-3.
It has been shown in experiments on mice that sodium diclofenac and indomethacin inhibited antibody titers and the number of rosette-forming cells (RFC) in mice immunized with sheep red blood cells. Sodium salicylate in all test doses did not produce any shifts in rosette-formation but lowered the number of RFC. As regards the immunodepressant activity, sodium diclofenac compares very favourably with indomethacin and sodium salicylate. Enhancement of the immunoreactivity inhibition caused by the drugs was not proportional to the increase in their antiphlogistic effects determined by the Selye model of inflammation.
在对小鼠的实验中已表明，双氯芬酸钠和吲哚美辛可抑制用绵羊红细胞免疫的小鼠的抗体滴度和玫瑰花结形成细胞（RFC）数量。所有测试剂量的水杨酸钠均未使玫瑰花结形成发生任何变化，但降低了RFC数量。就免疫抑制活性而言，双氯芬酸钠与吲哚美辛和水杨酸钠相比非常有利。药物引起的免疫反应性抑制增强与通过Selye炎症模型确定的其抗炎作用的增加不成比例。
