Rojo J M, Barasoain I, Portolés A
Int J Clin Pharmacol Ther Toxicol. 1981 May;19(5):220-2.
Oral administration of indomethacin inhibited immune response to sheep red blood cells in mice as assessed by direct plaque-forming cells. Serum titers, subsequent to immunization with Pseudomonas aeruginosa lipopolysaccharide, were also diminished in the indomethacin-treated mice. These effects were independent of both the antigen used as well as the magnitude of the primary immune response obtained. Prostaglandins are suggested to play a positive role in in vivo B cell proliferation and function.
通过直接斑块形成细胞评估，口服消炎痛可抑制小鼠对绵羊红细胞的免疫反应。在用铜绿假单胞菌脂多糖免疫后，消炎痛处理的小鼠血清滴度也降低。这些作用与所用抗原以及获得的初次免疫反应强度均无关。提示前列腺素在体内B细胞增殖和功能中起积极作用。
