• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

通过激活豚鼠输精管平滑肌中的毒蕈碱受体引发的电和机械事件。

Electrical and mechanical events through activation of muscarinic receptor in the smooth muscle of guinea-pig vas deferens.

作者信息

Wakui M, Fukushi Y, Inomata H

出版信息

Jpn J Physiol. 1984;34(3):557-60. doi: 10.2170/jjphysiol.34.557.

DOI:10.2170/jjphysiol.34.557
PMID:6492500
Abstract

Electrical and mechanical responses of the guinea-pig vas deferens to exogenous acetylcholine (ACh) were observed by means of a single sucrose-gap method. ACh at various concentrations evoked a contraction consisting of two components. The initial component seemed to be independent of a depolarization, while the second one was dependent on it. All ACh responses were abolished by Ca removal from the external solution. The results suggest the existence of a pathway by which ACh even at low concentrations causes a Ca influx without potential changes.

摘要

采用单蔗糖间隙法观察了豚鼠输精管对外源性乙酰胆碱(ACh)的电反应和机械反应。不同浓度的ACh均可引起由两个成分组成的收缩。初始成分似乎与去极化无关,而第二个成分则与之相关。从外部溶液中去除Ca后,所有ACh反应均被消除。结果提示存在一条途径,通过该途径即使低浓度的ACh也可在无电位变化的情况下引起Ca内流。

相似文献

1
Electrical and mechanical events through activation of muscarinic receptor in the smooth muscle of guinea-pig vas deferens.通过激活豚鼠输精管平滑肌中的毒蕈碱受体引发的电和机械事件。
Jpn J Physiol. 1984;34(3):557-60. doi: 10.2170/jjphysiol.34.557.
2
Requirements of external Ca and Na for the electrical and mechanical responses to noradrenaline in the smooth muscle of guinea-pig vas deferens.豚鼠输精管平滑肌对去甲肾上腺素的电反应和机械反应所需的细胞外钙和钠
Jpn J Physiol. 1984;34(1):199-203. doi: 10.2170/jjphysiol.34.199.
3
Effect of cobalt on electrical and mechanical responses to exogenous noradrenaline and to field stimulations in the guinea-pig vas deferens.钴对豚鼠输精管对外源性去甲肾上腺素和场刺激的电反应及机械反应的影响。
Jpn J Physiol. 1983;33(6):1057-60. doi: 10.2170/jjphysiol.33.1057.
4
Action of colchicine on cholinergic and adrenergic mechanisms in guinea pig vas deferens.秋水仙碱对豚鼠输精管胆碱能和肾上腺素能机制的作用。
Life Sci. 1981 Feb 23;28(8):851-60. doi: 10.1016/0024-3205(81)90046-1.
5
Regulation of muscarinic acetylcholine receptors and contractility of guinea pig vas deferens.毒蕈碱型乙酰胆碱受体的调节与豚鼠输精管的收缩性
Life Sci. 1981 Feb 2;28(5):527-40. doi: 10.1016/0024-3205(81)90146-6.
6
Dual excitatory actions of acetylcholine at the neuromuscular junction in the guinea-pig vas deferens.乙酰胆碱在豚鼠输精管神经肌肉接头处的双重兴奋作用。
Pflugers Arch. 1986 Jun;406(6):587-93. doi: 10.1007/BF00584025.
7
Inhibitory effect of methylmercuric chloride on the contraction mediated by muscarinic receptor of intestinal smooth muscle of the guinea-pig.氯化甲基汞对豚鼠肠平滑肌毒蕈碱受体介导收缩的抑制作用。
Tohoku J Exp Med. 1985 Sep;147(1):33-41. doi: 10.1620/tjem.147.33.
8
Sodium nitroprusside enhances contractions of the guinea-pig isolated vas deferens.硝普钠可增强豚鼠离体输精管的收缩。
J Pharm Pharmacol. 1998 Feb;50(2):205-9. doi: 10.1111/j.2042-7158.1998.tb06177.x.
9
A comparison of the effects of exogenous and endogenous prostaglandins on fast and slow contractions of field-stimulated guinea-pig vas deferens.外源性和内源性前列腺素对电场刺激的豚鼠输精管快速和慢速收缩作用的比较。
Br J Pharmacol. 1995 Nov;116(6):2679-84. doi: 10.1111/j.1476-5381.1995.tb17226.x.
10
Effects of ryanodine and nifedipine on contractions induced by norepinephrine, acetylcholine, and potassium in the isolated vas deferens of the guinea pig.ryanodine和硝苯地平对豚鼠离体输精管中去甲肾上腺素、乙酰胆碱和钾诱导的收缩的影响。
J Pharmacobiodyn. 1990 Sep;13(9):574-80. doi: 10.1248/bpb1978.13.574.

引用本文的文献

1
Dual excitatory actions of acetylcholine at the neuromuscular junction in the guinea-pig vas deferens.乙酰胆碱在豚鼠输精管神经肌肉接头处的双重兴奋作用。
Pflugers Arch. 1986 Jun;406(6):587-93. doi: 10.1007/BF00584025.