Mironov S L
Neirofiziologiia. 1984;16(4):445-51.
A model of electric excitability of mammalian neurons is developed based on described properties of the corresponding ionic currents. It is shown that these neurons may possess two types of rhythmic activity. The first type corresponds to the combination of the fast sodium and delayed potassium currents, the average period of membrane potential oscillations being 74 +/- 27 ms. The second type is determined by calcium and Ca-dependent potassium currents, and its interspike interval is equal to 850 +/- 40 ms. Two mechanisms of adaptation (elongation of the interspike interval) of rhythmic activity are predicted for these neurons. The former is determined by the fast potassium current and the latter is due to accumulation of calcium ions inside the cell and the development of Ca-dependent potassium conductance.
基于所描述的相应离子电流特性，建立了哺乳动物神经元电兴奋性模型。结果表明，这些神经元可能具有两种节律性活动。第一种类型对应于快速钠电流和延迟钾电流的组合，膜电位振荡的平均周期为74±27毫秒。第二种类型由钙电流和钙依赖性钾电流决定，其峰间间隔等于850±40毫秒。预测了这些神经元节律性活动的两种适应机制（峰间间隔延长）。前者由快速钾电流决定，后者是由于细胞内钙离子的积累和钙依赖性钾电导的发展。
