血管加压素注入清醒犬椎动脉循环的心血管效应。

Cardiovascular effects of vasopressin infused into the vertebral circulation of conscious dogs.

Liard J F, Dériaz O, Tschopp M, Schoun J

Clin Sci (Lond). 1981 Sep;61(3):345-7. doi: 10.1042/cs0610345.

Abstract

Seven conscious dogs received arginine-vasopressin infusions (100 and 1000 fmol min--1 kg--1) through catheters implanted in the left vertebral artery or the inferior vena cava while arterial pressure, cardiac output (electromagnetic flowmeter) and heart rate were measured. 2. Despite similar increases in plasma vasopressin concentrations, intravertebral administration induced a lesser increase in mean arterial pressure and a greater decrease in heart rate than the same infusion given intravenously. 3. These results suggest that vasopressin has an effect on structures of the central nervous system involved in cardiovascular control, possibly by affecting the baroreceptor reflex.

摘要

七只清醒的狗通过植入左椎动脉或下腔静脉的导管接受精氨酸加压素输注（100和1000飞摩尔·分钟⁻¹·千克⁻¹），同时测量动脉压、心输出量（电磁流量计）和心率。2. 尽管血浆加压素浓度有相似的升高，但与静脉内给予相同输注相比，椎体内给药引起的平均动脉压升高较小，心率下降较大。3. 这些结果表明，加压素可能通过影响压力感受器反射，对参与心血管控制的中枢神经系统结构产生作用。