Ebendal T, Lundin L G
Neurosci Lett. 1984 Sep 7;50(1-3):121-6. doi: 10.1016/0304-3940(84)90473-7.
The activity of nerve growth factor (NGF) in the salivary glands and in the sciatic nerve was compared between normal mice and mice affected by either of three neurological mutations by the use of a biological assay. No evidence was obtained for defects in amount or activity of NGF associated with the sprawling or splotch mutations. A reduction in the NGF content was found in salivary glands and sciatic nerve in homozygous dystonia musculorum mice. It is pointed out that the low amounts of NGF in dtJ/dtJ mice is likely to be a consequence of the general disturbances in development seen in this mutant rather than the specific cause for the neurological disorder.
通过生物学检测，比较了正常小鼠与受三种神经学突变之一影响的小鼠唾液腺和坐骨神经中神经生长因子（NGF）的活性。未获得与 sprawling 或 splotch 突变相关的 NGF 数量或活性缺陷的证据。在纯合性肌张力障碍小鼠的唾液腺和坐骨神经中发现 NGF 含量降低。需要指出的是，dtJ/dtJ 小鼠中 NGF 含量低可能是该突变体中普遍发育紊乱的结果，而非神经疾病的具体原因。
