Matsui K, Furukawa S, Shibasaki H, Kikuchi T
National Institute of Neuroscience, NCNP, Tokyo, Japan.
FEBS Lett. 1990 Dec 10;276(1-2):78-80. doi: 10.1016/0014-5793(90)80511-g.
By a highly sensitive enzyme immunoassay we measured the level of nerve growth factor (NGF) in the cerebellum and cerebrum of the neurologically mutant mice, weaver, reeler and Purkinje cell degeneration (PCD). A significant decrease in NGF level was observed in both cerebellum and cerebrum of weaver and reeler mutants of either sex. However, there was no such difference between normals and mutants in the case of the PCD mice. These results show that weaver and reeler mice have abnormalities of NGF synthesis and/or degradation not only in the cerebellum but also in the cerebrum.
通过一种高度灵敏的酶免疫测定法，我们测量了神经学突变小鼠（织工鼠、旋转鼠和浦肯野细胞变性小鼠）小脑和大脑中神经生长因子（NGF）的水平。在雌雄织工鼠和旋转鼠突变体的小脑和大脑中均观察到NGF水平显著降低。然而，在浦肯野细胞变性小鼠中，正常小鼠和突变小鼠之间没有这种差异。这些结果表明，织工鼠和旋转鼠不仅在小脑而且在大脑中都存在NGF合成和/或降解异常。
