Rainbow T C, Schwartz R D, Parsons B, Kellar K J
Neurosci Lett. 1984 Sep 7;50(1-3):193-6. doi: 10.1016/0304-3940(84)90485-3.
Quantitative autoradiography was used to localize nicotinic [3H]acetylcholine (ACh) binding sites in rat brain. High concentrations of nicotinic [3H]ACh binding sites were observed in the anterior and medial nuclei of the thalamus, the medial habenula and the superficial layer of the superior colliculus. Moderate levels of binding sites were observed in a variety of brain regions such as the frontoparietal cortex and the hippocampus. Low levels of nicotinic ACh sites occurred throughout the hypothalamus and the primary olfactory cortex.
采用定量放射自显影技术对大鼠脑中烟碱型[³H]乙酰胆碱(ACh)结合位点进行定位。在丘脑前核和内侧核、内侧缰核以及上丘表层观察到高浓度的烟碱型[³H]ACh结合位点。在额叶顶叶皮质和海马体等多种脑区观察到中等水平的结合位点。在下丘脑和初级嗅觉皮质中,烟碱型ACh位点含量较低。