Kato T, Ishii K, Ikeda M
Neurosci Lett. 1984 Sep 7;50(1-3):263-7. doi: 10.1016/0304-3940(84)90496-8.
In freely moving rats, effects of unilateral haloperidol injection into the substantia nigra were monitored with in vivo voltammetry in the bilateral striata. The electrochemical responses at 120 mV versus Ag-AgCl, reflecting mainly a level of 3,4-dihydroxyphenylacetic acid (DOPAC), increased both in the striata within 1.5 h after 5 micrograms of haloperidol treatment. In the experiments of high-performance liquid chromatography with electrochemical detection, the ratio of DOPAC to dopamine in the striata significantly increased at 2.75 h after drug treatment. These data support the idea that unilateral injection of haloperidol into the substantia nigra in freely moving rats increases dopamine turnover in the bilateral striata.
在自由活动的大鼠中，通过在双侧纹状体中进行体内伏安法监测向黑质单侧注射氟哌啶醇的效果。相对于Ag - AgCl在120 mV时的电化学响应，主要反映3,4 - 二羟基苯乙酸（DOPAC）的水平，在5微克氟哌啶醇处理后1.5小时内双侧纹状体中的该响应均增加。在高效液相色谱 - 电化学检测实验中，药物处理后2.75小时纹状体中DOPAC与多巴胺的比率显著增加。这些数据支持这样的观点，即向自由活动大鼠的黑质单侧注射氟哌啶醇会增加双侧纹状体中的多巴胺周转率。
