Ackil J E, Frommer G P
Physiol Behav. 1984 Jun;32(6):915-22. doi: 10.1016/0031-9384(84)90278-6.
Adult male albino rats were trained with water reinforcement on a lateralized visual discrimination task. For six rats the correct head turn--nose poke response was to the same side as the discriminative stimulus (Turn Towards group). For six others the correct response was to the side opposite from the discriminative stimulus (Turn Away group). Immediately after a rat had mastered its task, a unilateral electrolytic lesion was made under ether anesthesia through a stainless steel electrode previously implanted in the lateral hypothalamus (LH). Discrimination training continued until the rat's performance returned to criterion. The lesions produced contralateral neglect as demonstrated by deficits in turning and orientation contralateral to the lesion. The lesions also disrupted all measures of discrimination performance (% correct, latency, and duration of observing response) for trials on which responses contralateral to the lesion were correct, regardless of whether the discriminative stimulus was also contralateral (Turn Towards group) or was ipsilateral (Turn Away group). These data are interpreted as showing that contralateral neglect following LH lesions is associated with a deficit in initiating instrumental responses contralateral to the lesion. They also confirm previous results from a similar task using tactile discriminative stimuli.
成年雄性白化大鼠在一项侧化视觉辨别任务中接受水强化训练。对于六只大鼠，正确的转头——鼻尖轻触反应是朝向与辨别刺激相同的一侧（转向组）。对于另外六只大鼠，正确反应是朝向与辨别刺激相反的一侧（转离组）。在大鼠掌握任务后，立即在乙醚麻醉下通过先前植入外侧下丘脑（LH）的不锈钢电极进行单侧电解损伤。辨别训练持续进行，直到大鼠的表现恢复到标准。损伤导致对侧忽视，表现为损伤对侧的转头和定向缺陷。损伤还破坏了损伤对侧反应正确的试验中所有辨别表现的指标（正确百分比、潜伏期和观察反应持续时间），无论辨别刺激是在对侧（转向组）还是同侧（转离组）。这些数据被解释为表明LH损伤后的对侧忽视与启动损伤对侧的工具性反应的缺陷有关。它们还证实了先前使用触觉辨别刺激的类似任务的结果。
