Brasted P J, Dunnett S B, Robbins T W
MRC Cambridge Centre for Brain Repair, and Department of Experimental Psychology, University of Cambridge, UK.
Behav Brain Res. 2000 Jun 15;111(1-2):139-51. doi: 10.1016/s0166-4328(00)00147-9.
The present study assessed the behavioural sequalae of unilateral excitotoxic cortical lesions made either in the medial agranular cortex (AGm) or in the medial prefrontal cortex (mPFC) using a visual reaction time task. The task required animals to sustain a nose-poke in a central hole, until a brief light stimulus was presented in either of two holes which were located on the same side of the box: this enabled performance on each side of the rat's body to be assessed independently. Lesions of the AGm impaired performance on the contralateral side, with rats biasing their responding to the nearer of the two response locations. Analysis of the deficit revealed that rats were able to discriminate between the two stimuli and suggested that AGm lesions disrupted the control of contralateral responding. Lesions of the mPFC produced similar response-related deficits, but these were more transient in nature. Neither AGm lesions nor mPFC lesions impaired performance on the ipsilateral side, consistent with the concept of an egocentrically coded deficit.
本研究使用视觉反应时间任务评估了在内侧无颗粒皮质（AGm）或内侧前额叶皮质（mPFC）造成的单侧兴奋性毒性皮质损伤的行为后遗症。该任务要求动物持续将鼻子插入中央孔中，直到在位于盒子同一侧的两个孔中的任意一个出现短暂的光刺激：这使得能够独立评估大鼠身体每一侧的表现。AGm损伤会损害对侧的表现，大鼠会将反应偏向两个反应位置中较近的那个。对缺陷的分析表明，大鼠能够区分两种刺激，并表明AGm损伤破坏了对侧反应的控制。mPFC损伤产生了类似的与反应相关的缺陷，但这些缺陷本质上更短暂。AGm损伤和mPFC损伤均未损害同侧的表现，这与以自我为中心编码的缺陷概念一致。
