Franklin A, Coultas P
Radiat Res. 1984 Oct;100(1):55-64.
Both histological assessments and measurements of epidermal and dermal components are used to describe some effects of radiation on wound healing in mouse ear. A pattern of early wound closure followed by wound reopening was seen after doses of about 20 Gy and above. After 10 Gy X rays wound closure was comparable with that in unirradiated wounds but the nature of the tissue repair was different. The results suggested that the severity of radiation damage to epidermis is relatively unaffected by wounding but that the time course of expression of the radiation damage is appreciably accelerated. The observations are discussed in terms of their clinical relevance and of current radiobiological hypotheses.
组织学评估以及对表皮和真皮成分的测量都被用于描述辐射对小鼠耳部伤口愈合的一些影响。在约20 Gy及以上剂量照射后，出现了早期伤口闭合随后伤口重新裂开的模式。在10 Gy X射线照射后，伤口闭合情况与未照射伤口相当，但组织修复的性质不同。结果表明，辐射对表皮的损伤严重程度相对不受伤口影响，但辐射损伤的表达时间进程明显加快。根据这些观察结果的临床相关性以及当前的放射生物学假说进行了讨论。
