Vegesna V, Withers H R, Holly F E, McBride W H
Department of Radiation Oncology, UCLA Medical Center 90024-1714.
Radiat Res. 1993 Sep;135(3):431-3.
These experiments were designed to quantify the impact of local or systemic irradiation on the healing of full-thickness skin wounds in mice. Mice received total-body hemibody, or skin irradiations, prior to wounding. Wound tensile strength measured on day 14 was used as an end point. The dose to achieve an isoeffect of 40% of the tensile strength of the wounded controls was 13 Gy less for the total-body exposure than for local skin irradiation. Histological observation showed markedly fewer inflammatory cells in the wounded skin sections from total-body and hemibody-irradiated mice compared with those receiving only skin irradiation. These data demonstrate that the healing response in irradiated skin is dependent upon the extent of hematopoietic suppression and that at low doses this determines the outcome rather than damage to fixed target cells such as dermal fibroblasts, which are relatively resistant to radiation.
这些实验旨在量化局部或全身照射对小鼠全层皮肤伤口愈合的影响。小鼠在受伤前接受全身、半身或皮肤照射。以第14天测量的伤口抗张强度作为终点。全身照射达到受伤对照抗张强度40%等效应的剂量比局部皮肤照射少13 Gy。组织学观察显示，与仅接受皮肤照射的小鼠相比，全身和半身照射小鼠受伤皮肤切片中的炎症细胞明显更少。这些数据表明，受照射皮肤的愈合反应取决于造血抑制的程度，并且在低剂量时，这决定了结果，而不是对固定靶细胞（如相对抗辐射的真皮成纤维细胞）的损伤。
