通过电子显微镜技术对工业、化妆品和药用滑石粉中的石棉污染进行评估。

Evaluation by electron microscopy techniques of asbestos contamination in industrial, cosmetic, and pharmaceutical talcs.

作者信息

Paoletti L, Caiazza S, Donelli G, Pocchiari F

出版信息

Regul Toxicol Pharmacol. 1984 Sep;4(3):222-35. doi: 10.1016/0273-2300(84)90022-9.

Abstract

Talc powders from national and international markets were analyzed in order to assess their fiber contents and the proportion of asbestos in the fibrous material. Samples of talc powders used as excipients in pharmaceutical and cosmetic preparations demonstrated fiber contents up to 30% of total particles. About a half of the talc powders revealed the presence of asbestos: in five samples chrysotile (a serpentine asbestos) was present, in the other ones tremolite and anthophyllite (an amphibole asbestos). The amounts of asbestos vary up to 90% in the different samples of the fibrous fraction. About 75% of observed asbestos fibers were thinner than 0.4 micron, i.e., below the resolving power of light microscopy which until now was the most utilized technique for evaluating the environmental pollution due to asbestos.

摘要

为了评估国内外市场上滑石粉的纤维含量以及纤维状物质中石棉的比例，对其进行了分析。用作药物和化妆品制剂辅料的滑石粉样品显示，纤维含量高达颗粒总数的30%。大约一半的滑石粉中检测出石棉：五个样品中含有温石棉（一种蛇纹石石棉），其他样品中含有透闪石和直闪石（一种角闪石石棉）。不同纤维部分样品中的石棉含量差异高达90%。观察到的石棉纤维中约75%的直径小于0.4微米，即低于光学显微镜的分辨能力，而光学显微镜是迄今为止评估石棉环境污染最常用的技术。