Stewart T A, Bellvé A R, Leder P
Science. 1984 Nov 9;226(4675):707-10. doi: 10.1126/science.6494906.
In somatic cells the level of myc transcription is not restricted to particular cell types but correlates closely with the rate of cell division. Such transcription involves the use of two active myc promoters and produces two messenger RNA species that are differentially represented among the transcripts of different tissues. In apparent contrast to somatic cells, mitotically and meiotically dividing germ cells have very few myc transcripts and appear to proliferate, at least for a few divisions, in the absence of myc transcription. These results raise interesting questions regarding the role of the myc gene product in terminally differentiating cells, particularly of the germ line series.
在体细胞中，myc转录水平并不局限于特定细胞类型，而是与细胞分裂速率密切相关。这种转录涉及使用两个活跃的myc启动子，并产生两种信使RNA，它们在不同组织的转录本中差异表达。与体细胞明显不同的是，进行有丝分裂和减数分裂的生殖细胞中myc转录本很少，并且至少在最初几次分裂中，它们似乎在没有myc转录的情况下进行增殖。这些结果就myc基因产物在终末分化细胞，尤其是生殖细胞系中的作用提出了有趣的问题。
