Hansebout R R, Tanner J A, Romero-Sierra C
Spine (Phila Pa 1976). 1984 Jul-Aug;9(5):508-11. doi: 10.1097/00007632-198407000-00020.
In order to determine any beneficial effects of parenteral steroid administration and local cord cooling following complete cord injury, ten patients in the present series were treated by a combination of these modalities within 8 1/2 hours after injury. There was a better than expected rate of recovery of motor function and sensation and the mortality rate was reduced compared with more traditional forms of therapy. A literature review showed that local cord cooling had been applied to 52 patients with complete cord injuries in various centers. The rate of neurologic improvement was 48%, the ambulation rate was 17% and the 1-year mortality rate was reduced to 17%. These figures appear considerably better than the comparable expected rate for traditional treatment of such injuries. The results are encouraging enough to suggest further trials of treatment using localized cord cooling where such treatment can be instituted within 4 hours following injury.
为了确定完全性脊髓损伤后胃肠外给予类固醇和局部脊髓降温的任何有益效果，本系列中的10名患者在损伤后8个半小时内接受了这些治疗方式的联合治疗。与更传统的治疗方式相比，运动功能和感觉的恢复率好于预期，死亡率降低。文献综述显示，不同中心已将局部脊髓降温应用于52例完全性脊髓损伤患者。神经功能改善率为48%，行走率为17%，1年死亡率降至17%。这些数字似乎明显优于此类损伤传统治疗的预期可比率。这些结果足以令人鼓舞，表明在损伤后4小时内可进行局部脊髓降温治疗的情况下，应进一步开展相关治疗试验。
