Kiwerski J E
Metropolitan/Rehabilitation Centre, Konstancin, Poland.
Injury. 1993 Aug;24(7):457-60. doi: 10.1016/0020-1383(93)90149-z.
This communication evaluates the clinical efficacy of dexamethasone in acute spinal cord injury. The results of treatment in 290 patients given dexamethasone were compared with those of the control group of 330 patients not treated with corticosteroids. Patients with complete injuries and those with incomplete injuries showed greater improvement both quantitatively and qualitatively after treatment with dexamethasone than those without corticosteroids. The slightly increased risk of complications such as gastrointestinal bleeding and delayed wound healing was noted. It is recommended that corticosteroids should be used within the first hours after spinal cord injury.
本通讯评估了地塞米松在急性脊髓损伤中的临床疗效。将290例接受地塞米松治疗的患者的治疗结果与330例未接受皮质类固醇治疗的对照组患者的结果进行了比较。完全损伤和不完全损伤的患者在地塞米松治疗后，在定量和定性方面均比未使用皮质类固醇的患者有更大改善。注意到诸如胃肠道出血和伤口愈合延迟等并发症的风险略有增加。建议在脊髓损伤后的最初数小时内使用皮质类固醇。
