Bricolo A, Ore G D, Da Pian R, Faccioli F
Surg Neurol. 1976 Aug;6(2):101-6.
Eight patients with acute spinal cord injury at different levels were treated by local cooling. Early laminectomy was performed and the subdural space was irrigated with saline at 5degreesC for about two hours. In addition to this treatment, five patients, after closure of the operative wound, received local epidural cooling that was prolonged for a few days. All patients before treatment had a complete loss of function of the spinal cord below the injured segment. Four of these regained some sensory and motor functions and two were able to walk. Somatosensory cortical evoked responses were consistent with the results obtained, thus demonstrating their prognostic value. The clinical application of local spinal cord hypothermia in order to minimize the catastrophic effects of spinal cord trauma is discussed. The results obtained in these eight patients agree with the several experimental observations and seem to justify the application of this procedure to human beings.
8例不同节段急性脊髓损伤患者接受了局部降温治疗。早期进行了椎板切除术，并用5℃的生理盐水冲洗硬脑膜下间隙约两小时。除了这种治疗外，5例患者在手术伤口闭合后接受了局部硬膜外降温，并持续了几天。所有患者在治疗前受伤节段以下的脊髓功能完全丧失。其中4例恢复了一些感觉和运动功能，2例能够行走。体感皮层诱发电位与所获结果一致，从而证明了其预后价值。讨论了局部脊髓低温在减轻脊髓损伤灾难性后果方面的临床应用。这8例患者所获结果与多项实验观察结果相符，似乎证明了该方法在人类中的应用价值。
