Vollmer P J, Alexander T G, Haneke C
J Assoc Off Anal Chem. 1978 May;61(3):687-94.
A high pressure liquid chromatographic method for determining probenecid in oral suspensions of amoxicillin was applied to the determination of probenecid in oral suspensions of ampicillin. Three preparations containing various known amounts of probenecid in synthetic mixtures of ampicillin oral suspensions were analyzed by 5 chemists in an intralaboratory study, with satisfactory results. Blind duplicates of 3 prepared oral suspensions were sent to 12 collaborators, who were instructed to analyze the samples in a fixed random order. The standards showed a satisfactory linear response. Average recoveries of probenecid in the interlaboratory study for the 6 mixtures ranged from 95.2 to 99.1%, and the coefficients of variation ranged from 1.63 to 4.9%.
一种用于测定阿莫西林口服混悬液中丙磺舒的高压液相色谱法被应用于氨苄西林口服混悬液中丙磺舒的测定。在一项实验室内部研究中，5位化学家对含有不同已知量丙磺舒的氨苄西林口服混悬液合成混合物的三种制剂进行了分析，结果令人满意。将3种制备好的口服混悬液的盲样复制品寄给了12位合作者，并指示他们按照固定的随机顺序分析样品。标准品显示出令人满意的线性响应。在实验室间研究中，6种混合物中丙磺舒的平均回收率为95.2%至99.1%，变异系数为1.63%至4.9%。
