含氨苄西林片剂和调味口服混悬液中丙磺舒测定方法的比较。
Comparison of methods for determining probenecid in tablets and flavored oral suspensions containing ampicillin.
作者信息
Vollmer P J, Chastonay R, Haneke C, Kantor N, Blyth R
出版信息
J Assoc Off Anal Chem. 1977 Nov;60(6):1345-9.
Several methods for quantitating probenecid were compared: USP XIX method for probenecid in tablets, a modified USP extraction method for probenecid in tablets, a new column extraction method for probenecid in tablets and oral suspensions containing ampicillin, and a high pressure liquid chromatographic (HPLC) method for probenecid in tablets and oral suspensions containing antibiotics. The first 3 methods were satisfactory for probenecid in bulks and tablets but proved unsatisfactory for oral suspeonsions containing flavors. The flavors gave positive interference for probenecid in oral suspensions. The HPLC method, although more time-consuming, separated probenecid from excipients, thus eliminating positive interference from flavors.
对几种丙磺舒定量方法进行了比较
美国药典第十九版中片剂中丙磺舒的测定方法、片剂中丙磺舒的改良美国药典提取方法、含氨苄西林的片剂和口服混悬剂中丙磺舒的新柱提取方法以及含抗生素的片剂和口服混悬剂中丙磺舒的高压液相色谱（HPLC）方法。前三种方法对原料药和片剂中的丙磺舒测定效果良好，但对含香料的口服混悬剂测定效果不佳。香料对口服混悬剂中的丙磺舒产生正干扰。HPLC方法虽然耗时更长，但能将丙磺舒与辅料分离，从而消除了香料的正干扰。
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