Unanov S S, Pille E R, Levchenko E N, Karakuiumchan M K, Iuminova N V
Vopr Virusol. 1984 Jul-Aug;29(4):437-41.
Immunization with a vaccine prepared from sheep-brain-grown fixed rabies virus inactivated with beta-propiolactone was given to 146 subjects. The vaccine was by 80-90% purified from waste brain tissue substances (protein content less than 2 mg/ml) and showed no neuroallergenicity in guinea pig tests. Simultaneously 86 subjects were vaccinated with commercial Fermi vaccine. Immunization was performed according to the schedules accepted in the USSR. The new vaccine produced much fewer local reactions than Fermi vaccine (in 39.6% and 60.9% vaccinees, respectively) and 5 times as few systemic reactions (in 6.03% and 31.3% vaccinees, respectively). The antigenic potency of the new vaccine was as good as that of Fermi vaccine.
用由羊脑培养的固定狂犬病病毒经β-丙内酯灭活制成的疫苗对146名受试者进行了免疫接种。该疫苗从废弃脑组织物质中纯化了80 - 90%（蛋白质含量低于2毫克/毫升），在豚鼠试验中未显示出神经变应原性。同时，86名受试者接种了市售的费米疫苗。免疫接种按照苏联认可的方案进行。新疫苗产生的局部反应比费米疫苗少得多（分别为39.6%和60.9%的接种者），全身反应少5倍（分别为6.03%和31.3%的接种者）。新疫苗的抗原效力与费米疫苗相当。
