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[采用缩短接种程序接种的由脑组织制成的紫外线灭活抗狂犬病疫苗的比活性]

[Specific activity of an UV-inactivated antirabies vaccine made from brain tissue administered in a shortened schedule].

作者信息

Morogova V M, Magazov R Sh, Gil'dina S S, Latypova R G, Shafeeva R S

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1982 Apr(4):98-101.

PMID:7080770
Abstract

The results obtained in the study of the specific potency of rabies vaccine prepared from sheep brain tissue and inactivated by UV irradiation indicate that, even in the presence of the lowest immunogenicity index (0.5), 5-6 injections of the vaccine, made not daily, but at interval of 3 and 7 days, induced the production of antibodies in the titers not lower than those resulting from 14-20 daily injections of the same vaccine or Fermi vaccine. The preparation inactivated by UV irradiation should be introduced for therapy according to the shortened immunization schedule with intervals, taking into account the immunogenicity index.

摘要

对由羊脑组织制备并经紫外线照射灭活的狂犬病疫苗的比活性研究结果表明,即使在免疫原性指数最低(0.5)的情况下,每隔3天和7天注射5 - 6次该疫苗(而非每日注射),诱导产生的抗体效价不低于每日注射14 - 20次相同疫苗或费米疫苗所产生的抗体效价。考虑到免疫原性指数,应根据缩短的免疫接种时间表,间隔注射经紫外线照射灭活的制剂用于治疗。

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