Martin R, Martin H, Rotzsch W
Z Alternsforsch. 1984 Sep-Oct;39(5):253-61.
By means of the experimental-gerontological literature the question of causality between oxygen and ageing and the age-associated alterations, influencing oxygen utilisation, were discussed. Under normal conditions there are no significant decreases of high-energy compounds in the most organs, although under a strain of organism it is possible to show a reduction of adaptation and regulation on different levels. Oxygen deficiency as a primary cause of ageing could not be showed experimentally. On the other hand the classification of free radicals (= the products of oxygen activation) as primary factors of ageing are more conceivable. The estimation of causal relations is difficult because of the interlocking of physiological and pathological processes of ageing.
借助实验老年学文献，讨论了氧气与衰老之间的因果关系以及影响氧气利用的与年龄相关的变化。在正常情况下，大多数器官中高能化合物没有显著减少，尽管在机体应激状态下，不同水平的适应性和调节功能可能会降低。实验未能证明缺氧是衰老的主要原因。另一方面，将自由基（= 氧气活化产物）归类为衰老的主要因素更具可信度。由于衰老的生理和病理过程相互交织，因果关系的评估很困难。
